Mentioning Pepe Le Pew's hijinx got me wondering how closely related cats and skunks are. And it turns out: pretty close (links to a powerpoint presentation from a textbook). Skunks (Mephitis mephitis) are part of the family of mustelids, which are the nearest family to felidae, including the domestic housecat (Felis catus). They're also closer in relation to puppys (canids) than cats are, which perhaps explains why I've heard they make great pets (if stink gland is removed). Not an experiment I'll be trying any time soon. And by way of correction to what's below, it seems that it was the cat who was accidentally painted to look like Le Pew's smelly paramour, not the other way around.